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KMID : 0043319970200060633
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Archives of Pharmacal Research
1997 Volume.20 No. 6 p.633 ~ p.636
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Platelet-Activating Factor Antagonistic Activity and ^13C NMR Assignment of Pregomisin and Chamigrenal from Schisandra chinensis
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Lee Im-Seon
Jung Keun-Young
Oh Sei-Ryang
Kim Dong-Seon
Kim Jung-Hee
Lee Jung-Joon
Lee Hyeong-Kyu
Lee Seung-Ho
Kim Eun-Hee
Cheong Chae-Joon
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Abstract
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In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the values were respectively. In addition, the NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
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KEYWORD
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Schisandra chinensis Baill, Schisandraceae, PAF receptor antagonist, pregomisin, chamigrenal, C NMR
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